Kwyj1b0 writes: In a massive study on genetic variation among humans, researchers found that most changes occurred in the last 200 generations, too fast for natural selection to catch up. Recent papers show that rare genetic variations have a more drastic effect than previously believed. Another result shows that "we carry a much larger load of deleterious variants" (as well as positive variants) than our ancestors 200 generations ago.
"The eleventh commandment was `Thou Shalt Compute' or `Thou Shalt Not
Compute' -- I forget which."
-- Epigrams in Programming, ACM SIGPLAN Sept. 1982