rtoz writes: Google's moonshot research division, "Google X," has started "Baseline Study," a project designed to collect anonymous genetic and molecular information from 175 people (and later thousands more) to create a complete picture of what a healthy human being should be. The blueprint will help researchers detect health problems such as heart disease and cancer far earlier, focusing medicine on prevention rather than treatment. According to Google, the information from Baseline will be anonymous, and its use will be limited to medical and health purposes. Data won't be shared with insurance companies.
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First time accepted submitter Leslie Oliver Karpas writes As millions of Americans with Obstructive Sleep Apnea struggle to get a good night's sleep, one company has harnessed 3D technology to revolutionize CPAP therapy. As 3ders.org reported today, "Metamason is working on custom CPAP masks for sleep apnea patients via 3D scanning, smart geometry, and 3D printing." "We're at the crossroads of 3D technology and personalized medicine," says Metamason's founder and CEO. "There are many medical products that would be infinitely more comfortable and effective with a customized fit. CPAP therapy is the perfect example—it's a very effective treatment with a 50% quit rate, because mass-produced masks are uncomfortable and don't fit properly." CPAP is a respiratory device worn during sleep to treat OSA, which affects 1 in 4 men and 1 in 9 women in the US alone. Metamason's "ScanFitPrint" process for creating their custom Respere masks translates a 3D scan of the patient's face into a 3D printed custom mask that is a perfect individual fit. To print the masks in soft, biocompatible silicone, Metamason invented a proprietary 3D printing process called Investment Molding, which creates wholly integrated products that were previously considered "unmoldable."
gunner_von_diamond (3461783) happened upon Ask Slashdot: Experiences with Laser Eye Surgery from ten years ago, and asks: I was just reading a story on /. from 10 years ago about Lasik Eye Surgery. Personally, I've had Lasik done and loved every single part of the surgery. I went from wearing contacts/glasses every day to having 20/15 vision! In the older post, everyone seemed to be cautious about it, waiting for technical advances before having the surgery. Today, the surgery is fairly inexpensive [even for a programmer :) ], takes about 10-15 minutes, and I recovered from the surgery that same day. So my question is: what is holding everyone else back from freeing themselves from contacts and glasses?
symbolset writes in with the latest about an ebola outbreak spreading across West Africa. The World Health Organization (WHO) continues to monitor the evolution of the Ebola virus disease (EVD) outbreak in Sierra Leone, Liberia, and Guinea. The current epidemic trend of EVD outbreak in Sierra Leone and Liberia remains serious, with 67 new cases and 19 deaths reported July 15-17, 2014. These include suspect, probable, and laboratory-confirmed cases. The EVD outbreak in Guinea continues to show a declining trend, with no new cases reported during this period. Critical analyses and review of the current outbreak response is being undertaken to inform the process of developing prioritized national operational plans. Effective implementation of the prioritized plans will be vital in reversing the current trend of EVD outbreak, especially in Liberia and Sierra Leone.
Lasrick writes: MIT's Jeanne Guillemin looks at the recent blunders with smallpox and H5N1 at the Centers for Disease Control and the National Institutes of Health to chronicle the fascinating history of smallpox eradication efforts and the attempts (thwarted by Western scientists) to destroy lab collections of the virus in order to make it truly extinct. "In 1986, with no new smallpox cases reported, the World Health Assembly, the decision-making body of the WHO, resolved to destroy the strain collections and make the virus extinct. But there was resistance to this; American scientists in particular wanted to continue their research." Within a few years, secret biological warfare programs were discovered in Moscow and in Iraq, and a new flurry of defensive research was funded. Nevertheless, Guillemin and others believe that changes in research methods, which no longer require the use of live viruses, mean that stocks of the live smallpox virus can and should finally be destroyed.
rtoz (2530056) writes A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells. A new study from MIT materials scientists reveals that these nanoparticles enter cells by taking advantage of a route normally used in vesicle-vesicle fusion, a crucial process that allows signal transmission between neurons. MIT engineers created simulations of how a gold nanoparticle coated with special molecules can penetrate a membrane. Paper (abstract; full text paywalled).
New submitter structural_biologist writes: Genes normally have a 50-50 chance of being passed from parent to offspring, but scientists may have figured out a way to create genes that show up in offspring with a much higher frequency. "One type of gene drive influences inheritance by copying itself onto chromosomes that previously lacked it. When an organism inherits such a gene drive from only one parent, it makes a cut in the chromosome from the other parent, forcing the cell to copy the inheritance-biasing gene drive—and any adjacent genes—when it repairs the damage." When introduced into the wild, organisms containing gene drives would breed with the population, quickly spreading the modified genes throughout the ecosystem. While the technology could help prevent the spread of malaria and manage invasive species, many scientists worry about the wide-ranging effects of such a technology and are calling for its regulation.
Zothecula (1870348) writes Pacemakers serve an invaluable purpose, by electrically stimulating a recipient's heart in order to keep it beating at a steady rate. The implantation of a pacemaker is a major surgical procedure, however, plus its presence in the body can lead to complications such as infections. Now, for the first time, scientists have instead injected genes into the defective hearts of pigs, converting unspecialized heart cells into "biological pacemakers." Research Paper (abstract, full text paywalled).
multicsfan writes Researchers have found that an injection of protein FGF1 stops weight induced diabetes in mice, with no apparent side effects. However, the cure only lasts 2 days at a time. Future research and human trials are needed to better understand and create a working drug. From the story: "The team found that sustained treatment with the protein doesn't merely keep blood sugar under control, but also reverses insulin insensitivity, the underlying physiological cause of diabetes. Equally exciting, the newly developed treatment doesn't result in side effects common to most current diabetes treatments."
aarondubrow (1866212) writes The "valley of death" is well-known to entrepreneurs — the lull between government funding for research and industry support for prototypes and products. To confront this problem, in 2013 the National Science Foundation created a new program called InTrans to extend the life of the most high-impact NSF-funded research and help great ideas transition from lab to practice. Today, in partnership with Intel, NSF announced the first InTrans award of $3 million to a team of researchers who are designing customizable, domain-specific computing technologies for use in healthcare. The work could lead to less exposure to dangerous radiation during x-rays by speeding up the computing side of medicine. It also could result in patient-specific cancer treatments.
schwit1 (797399) writes FDA officials now admit that when they discovered six undocumented vials of smallpox in a facility in Maryland they also found 327 additional vials that contained dengue, influenza, and rickettsia. "FDA scientists said they have not yet confirmed whether the newly disclosed vials actually contained the pathogens listed on their labels. The agency is conducting a nationwide search of all cold storage units for any other missing samples. Investigators destroyed 32 vials containing tissue samples and a non-contagious virus related to smallpox. Several unlabeled vials were sent to the Centers for Disease Control and Prevention for testing and the remaining 279 samples were shipped to the Department of Homeland Security for safekeeping." The FDA's deputy director is quoted with what might be the understatement of the year. "The reasons why these samples went unnoticed for this long is something we're actively trying to understand."
vrml writes In medicine, it is well-known that sugar pills sometimes produce the same effects as real drugs (Placebo Effect). But could that happen with computers too? The first scientific study of the Placebo Effect in computing, just published by the International Journal of Human-Computer Studies , gives an affirmative answer. The experiment considered affective computing, that is those fancy applications that claim to know user's emotions by detecting physiological parameters with sensors. Researchers took two well-known affective computing systems and used them to control in real-time the state of an avatar that looked more and more nervous as users' stress level increased, and more and more relaxed as it decreased. But they also considered a third system in which, unbeknown to users, the sensors were disconnected from the computer and the avatar state was controlled by a random stream of physiological data instead of the real user's data. Results show that participants believed that the sham application was able to display their stress level. Even worse, only one of the two (costly) affective computing systems produced better results than the placebo. This suggests that evaluations of such novel computer applications should include also a placebo condition, as it is routinely done in medicine but not yet in computer science.
meghan elizabeth writes How do you get weed without the weed? By genetically engineering yeast to produce THC, of course. Once theorized in a stoner magazine column more than a decade ago, a biotech startup working in Ireland is actively trying to transplant the genetic information that codes for both THC and another cannabinoid called CBD into yeast so that "marijuana" can be grown in a lab—no plants necessary.
An anonymous reader writes: Many prominent news organizations, including the BBC, are reporting on a study (PDF) that claims a new blood test is 87% accurate in predicting which patients will develop cognitive impairment. It's hailed as a major step forward in efforts to fight dementia and Alzheimer's disease. Unfortunately, reality isn't quite so impressive. An article at MedPage Today explains all of the statistical facts that the mainstream press glosses over: "Only about 10% of patients of patients with MCI convert to clinical dementia per year. With nearly 30% of positive results false (remember, the specificity was 71%) as well as 15% of negative results false, most of the positive results in such a group will be false. Yes, it's time once again for a tutorial in positive predictive values. If we have 100 MCI patients and a 10% conversion rate, then 10 of them will develop dementia. These are the true positives. There will be 90 true negatives — the ones who don't convert. But with a specificity of 71%, the test will falsely identify 29% of the 90 true negatives, or 26, as positive. Meanwhile, with a false negative rate of 15%, only nine (rounding up from 8.5) of the 10 true positives will be correctly identified. ... It's easy to get a high negative predictive value when the annual event rate is 10%. If I simply predict that no one will convert, I'll be right 90% of the time."
itwbennett (1594911) writes "The Social Security numbers of roughly 18,000 California physicians and health-care providers were inadvertently made public after a slip-up at health insurance provider Blue Shield of California, the organization said Monday. The numbers were included in monthly filings on medical providers that Blue Shield is required to make to the state's Department of Managed Health Care (DMHC). The provider rosters for February, March and April 2013 included the SSNs and other sensitive information and were available under the state's public records law." Ten copies were requested under the public records law.
chicksdaddy writes Mobile health and wellness is one of the fastest growing categories of mobile apps. Already, apps exist that measure your blood pressure and take your pulse, jobs traditionally done by tried and true instruments like blood pressure cuffs and stethoscopes. If that sounds to you like the kind of thing the FDA should be vetting, don't hold your breath. A senior advisor to the U.S. Food and Drug Administration (FDA) has warned that the current process for approving medical devices couldn't possibly meet the challenge of policing mobile health and wellness apps and that, in most cases, the agency won't even try. Bakul Patel, and advisor to the FDA, said the Agency couldn't scale to police hundreds of new health and wellness apps released each month to online marketplaces like the iTunes AppStore and Google Play.
Zothecula writes If you're going to deploy robots in biological settings – for example, inside the body – it makes a lot of sense to build those robots out of actual biological body parts. Muscle, for example, is a very effective, biodegradable replacement for an electric actuator that can run in a nutrient-rich fluid without the need for any other power source. Bio-robotics experts in Illinois have demonstrated a bio-bot built from 3-D printed hydrogel and spinal muscle tissue that can "walk" in response to an electrical signal. Their next step will be trying to incorporate neurons that can get the bot walking in different directions when faced with different stimuli.
An anonymous reader writes In a legislative first, the U.S. Supreme Court ruled on Monday that for-profit companies can, in essence, hold religious views. Given the Supreme Court's earlier decisions granting corporations the right to express political support through monetary donations, this ruling is not all that surprising. Its scope does not extend beyond family-owned companies where "there's no real difference between the business and its owners." It also only applies to the contraception mandate of the health care law. The justices indicated that contraceptive coverage can still be obtained through exceptions to the mandate that have already been introduced to accommodate religious nonprofits. Those exceptions, which authorize insurance companies to provide the coverage instead of the employers, are currently being challenged in lower courts. The "closely held" test is pretty meaningless, since the majority of U.S. corporations are closely held.
An anonymous reader writes UNYQ (pronounced: unique), a start-up based in San Francisco and Seville, has set out to change the way we look at prosthetics by selling affordable 3D printed prosthetic leg covers, known as "fairings," directly to consumers. The company was co-founded by Eythor Bender, who is best known for developing a prototype bionic exoskeleton that allows paraplegics to walk again. Bender, who has worked with the disabled for over 20 years, was frustrated by the lack of consideration of style in the medical device development process. Despite all the progress made in other areas, the devices still look more or less like a "wooden stick." Bender wants to challenge what we think is possible with prosthetics.
schwit1 (797399) sends word of a new and exciting use for all of the data various entities are collecting about you. From the article: You may soon get a call from your doctor if you've let your gym membership lapse, made a habit of ordering out for pizza or begin shopping at plus-sized stores. That's because some hospitals are starting to use detailed consumer data to create profiles on current and potential patients to identify those most likely to get sick, so the hospitals can intervene before they do. Acxiom Corp. (ACXM) and LexisNexis are two of the largest data brokers who collect such information on individuals. They say their data are supposed to be used only for marketing, not for medical purposes or to be included in medical records. While both sell to health insurers, they said it's to help those companies offer better services to members.